View Sickle Cell Anemia Pathophysiology UK. The most common type is known as sickle cell anaemia (sca). People with sickle cell anemia have an increased risk of serious infection, and fever can be the first sign of an infection.
Sickle cell anemia, hereditary disease that destroys red blood cells by causing them to take on a rigid 'sickle' shape.
The anemia results from the markedly shortened circulatory survival of ss cells, together with a limited erythropoietic response. Sickle cell anemia is due to an autosomal recessive allele which is found on the short arm of chromosome 11. In this article we plan to discuss the clinical features of the disorder and describe current concepts of diagnosis. Sickle cell anemia is a hereditary disorder of the red blood cells that primarily affects african americans.